Esta técnica, si bien está vigente desde hace años en Estados Unidos y Europa es novedosa en nuestro país. Resuelve patología de columna con resultados satisfactorios, disminuyendo significativamente la necesidad de realizar una cirugía.

El Dr. Estévez realiza dicha técnica junto al Equipo Médico del Instituto de Traumatología Barcelona de España, pioneros en la aplicación de Plasma rico en Columna. Su director, el Dr. Fernando Kirchner es integrante del Biotechnology Institute de España (BTI), Centro de referencia donde se han desarrollado y perfeccionado las terapias más avanzadas, hoy aplicadas en prestigiosos Hospitales y Sanatorios.

Dr. Fernando Kirchner junto al Dr. Martin Estévez

La tecnología PRGF-ENDORET desarrollada y patentada por el Dr. Eduardo Anitua, Fundador del Biotechnology Institute de España, fue la primera técnica para la obtención de plasma rico en factores de crecimiento en contar con el aval científico internacional.
Esta tecnología cumple con la Resolución publicada por la Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) para la obtención de plasma rico en factores de crecimiento y su uso como medicamento para el ser humano.
Sus excelentes resultados terapéuticos en diversas áreas de la medicina están avalados por múltiples ensayos clínicos y publicaciones científicas desde 1997. Innumerables premios Internacionales destacan dicho esfuerzo.

El Dr. Martín Estévez es especialista con experiencia, estudio y dedicación a la técnica de Plasma rico en plaquetas desde el año 2008. Ha realizado múltiples viajes internacionales de perfeccionamiento y capacitación para profundizar en los últimos avances con el fin de mejorar aún más la calidad de vida de sus pacientes.

Conferencista internacional:

Los discos intervertebrales y las articulaciones facetarias son dos estructuras espinales fundamentales especializadas en la amortiguación y soporte.

En respuesta al estrés mecánico, sinovitis y artrosis vertebral, estas estructuras son objeto de un proceso de deterioro degenerativo crónico que conduce al dolor lumbar. El envejecimiento es otro factor que produce cambios degenerativos en la columna, los cuales son predominantemente causa de dolor de espalda y ciática en la población adulta.

Este moderno enfoque de tratamiento contribuye a la regeneración de tejidos, limita rápidamente el dolor recuperando movilidad y calidad de vida. Además reduce significativamente la necesidad de realizar largas cirugías que exponen al paciente a riesgos y complicaciones.

• Reducción rápida y duradera del dolor.

• Eliminación del «ambiente inflamatorio» de la articulación.

• Aumento de la síntesis colágeno tipo 2.

• Generación de efecto condroprotector gracias al aumento de la síntesis de ácido hialurónico.

• Disminución de la apoptosis celular (muerte celular).

• Recuperación del rango de movilidad articular.

Vertebral intraosseous plasma rich in growth factor (PRGF-Endoret) infiltrations as a novel strategy for the treatment of degenerative lesions of endplate in lumbar pathology: description of technique and case presentation.Fernando Kirchner, Ariadna Pinar, Isidro Milani, Roberto Prado, Sabino Padilla & Eduardo Anitua Journal of Orthopaedic Surgery and Research volume 15, Article number: 72 (2020)

Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors reduce pain in patients with chronic low back pain. Kirchner F1, Anitua E2. J Craniovertebr Junction Spine. 2016 Oct-Dec;7(4):250-256.

Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial Koji Akeda1, Kohshi Ohishi2, Koichi Masuda3, Won C. Bae4, Norihiko Takegami1, Junichi Yamada1, Tomoki Nakamura1, Toshihiko Sakakibara5, Yuichi Kasai5, Akihiro Sudo1 Asian Spine Journal 2017;11(3):380-389.

Regenerative injection treatment in the spine: review and case series with platelet rich plasma. J Stem Cells Res
D Aufiero, H Vincent, S Sampson, M Bodor – Rev & Rep, 2015 – houstonsportsdoctor.com

Pain Physician. 2019 Jan;22(1S):S1-S74.
Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain. American Society of Interventional Pain Physicians (ASIPP) Guidelines. Navani A1, Manchikanti L2, Albers SL, Latchaw RE, Sanapati J3, Kaye AD4, Atluri S5, Jordan S, Gupta A6, Cedeno D7, Vallejo A8, Fellows B, Knezevic NN9. Pain Physician. 2019 Jan;22(1S):S1-S74.

Biologic therapies to enhance intervertebral disc repair. Eduardo Anitua & Sabino Padilla. REGENERATIVE MEDICINEVOL. 13, NO. 1

Increased Nuclear T2 Signal Intensity and Improved Function and Pain in a Patient One Year After an Intradiscal Platelet–Rich Plasma Injection Gregory E. Lutz, MD. Pain Medicine, Volume 18, Issue 6, June 2017, Pages 1197–1199

Regenerative injection treatment in the spine: review and case series with platelet rich plasma. J Stem Cells Res. D Aufiero, H Vincent, S Sampson, M Bodor – Rev & Rep, 2015 –

Treatment of symptomatic degenerative intervertebral discs with autologous platelet-rich plasma: follow-up at 5–9 years Jennifer Cheng, Kristen A Santiago, Joseph T Nguyen, Jennifer L Solomon & Gregory E Lutz. REGENERATIVE MEDICINEVOL. 14, NO. 9. 29 Aug 2019

Lumbar Intradiskal Platelet‐Rich Plasma (PRP) Injections: A Prospective, Double‐Blind, Randomized Controlled Study Yetsa A. Tuakli‐Wosornu MD, MPH Alon Terry MD Kwadwo Boachie‐Adjei BS, CPH CME 24 August 2015

Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar
Christine M.E. Rustenburg Kaj S. Emanuel Mirte Peeters Willem F. Lems . JOR Spine. 28 August 2018

Human-Based Biological and Biomimetic Autologous Therapies for Musculoskeletal Tissue Regeneration Eduardo Anitua, Mikel Sánchez, Sabino Padilla, Gorka Orive. Trends in Biotechnology. December 19, 2016

Is exclusion of leukocytes from platelet-rich plasma (PRP) a better choice for early intervertebral disc regeneration? Shan- zheng Wang, Wei-min Fan, Jun Jia, Liang-yu Ma, Jia-bin Yu & Chen Wang Stem Cell Research & Therapy. volume 9, Article number: 199 (2018)

Intervertebral disc regeneration: do nutrients lead the way? Yong-Can Huang, Jill P. G. Urban & Keith D. K. Luk, Nature Reviews Rheumatology volume 10 lag, 561-566 (2014)

Intervertebral disc degeneration: evidence for two distinct phenotypes. Michael A. Adams Patricia Dolan. Journal of Anatomy . 2012

The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. Eduardo Anitua, Mikel Sánchez, Gorka Orivea, Isabel Andía. 2007.

Regenerative Treatments for Spinal Conditions. Angelie Mascarinas MD, Julian Harrison, Gregory Lutz MD. Physical Medicine and Rehabilitation Clinics of North America. Volume 27, Issue 4, November 2016, Pages 1003-1017

What is the clinical evidence on regenerative medicine in intervertebral disc degeneration? M. Basso, L. Cavagnaro, A. Zanirato, S. Divano, C. Formica, M. Formica & L. Felli . MUSCULOSKELETAL SURGERY. Volume 101, pages 93-104 (2017)

Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs
Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs. S. Rajasekaran, K. Venkatadass, J. Naresh Babu, European Spine Journal, volume 17, pages 626-643 (2008).

Anitua E, Prado R, Nurden AT, Nurden P: Characterization of plasma rich in growth factors (PRGF): components and formulations. Anitua E, Prado R, Nurden AT, Nurden P. Platelet Rich Plasma in Orthopaedics and Sports Medicine. Edited by Anitua E, Cugat R, Sánchez M. Cham: Springer International Publishing; 2018: 29-45

Leukocytes enhance inflammatory and catabolic degenerative changes in the intervertebral disc after endplate fracture in vitro without infiltrating the disc. Dudli S, Boffa DB, Ferguson SJ, Haschtmann D. Spine. 2015;40(23):1799–806.

Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes. Gersh KC, Nagaswami C, Weisel JW. Thromb Haemost. 2009;102(6):1169–75.

Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. Michael Monfett, Julian Harrison, Kwadwo Boachie-Adjei & Gregory Lutz International Orthopaedics 2016

Regenerative Treatments for Spinal Conditions Angelie Mascarinas, MD, Julian Harrison, BS, Kwadwo Boachie-Adjei, BS, CPH, Gregory Lutz, MD Physical Medicine .2016

Intervertebral Disc Regeneration Using Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel Microspheres. Masateru Nagae, Takumi Ikeda, Yasuo Mikami, Hitoshi Hase, Hitoshi Ozawa, Ken-Ichi Matsuda, Hirotaka Sakamoto, Yasuhiko Tabata, Mitsuhiro Kawata, and Toshikazu Kubo. Tissue EngineeringVol. 13, No. 1 2007

Ankylosing Spondylitis Versus Internal Disc Disruption: A Case Report Treated Successfully with Intradiscal Platelet-Rich Plasma Injection. Richard G. Chang, Nicole R. Hurwitz, Gregory E. Lutz. 2017

Epidural platelet-rich plasma (PRP) for discogenic back pain. José Correa, MD. Fundación Universitaria JN Corpas – Bogotá, Colombia, Bogotá. 2018.

Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy. Shan- Zheng W, Yun-Feng R, Qi T, Chen W. Arthritis Res Ther. 2013; 15(5): 220.

Correa J, Cortés H, Coral O, E. García E. PRP epidural en el manejo de la enfermedad discal degenerativa y dolor axial. Estudio preliminar. Correa J, Cortés H, Coral O, E. García E. Rev. Soc. Esp. Dolor 2017; 24(2): 85-95.

Platelet-rich plasma injections: an emerging therapy for chronic discogenic low back pain. Suja Mohammed1 and James Yu J Spine Surg. 2018 Mar; 4(1): 115–122. Suja Mohammed1 and James Yu.

Platelet rich plasma application in chronic low back pain – clinical and anatomical rationale and review of the literature. Plamen Todorov Todorov+ L. Mekenjan+ S. Popova+ A. Batalov+. Revmatologiia (Buelgaria).Vol 27 No 4 (2019) December 30, 2019.

Platelet-rich plasma in the management of chronic low back pain: a critical review. J Pain Res. 2019; 12: 753–767. Koji Akeda,1 Junichi Yamada,1 Erikka T Linn,2 Akihiro Sudo,1 and Koichi Masuda2

Application of Platelet-Rich Plasma to Enhance Tissue Repair. Andrew P.WroblewskiBSHector A.MejiaMDVonda J.WrightMD. Operative Techniques in Orthopaedics. Volume 20, Issue 2, June 2010, Pages 98-105

Anti‐inflammatory effect of platelet‐rich plasma on nucleus pulposus cells with response of TNF‐α and IL‐1
Ho‐Joong Kim Jin S. Yeom Yong‐Gon Koh Jee‐Eun Yeo Kyoung‐Tak Kang. December 2013

Use of Platelet-Rich Plasma in Treating Low Back Pain: A Review of the Current Literature. Mirza Zain Baig1, Umm E Hani Abdullah2, Aun Muhammad3, Abeer Aziz4, Maryam Jamil Syed5, Aneela Darbar6. Asian Spine Journal 2020;asj.2019.0161.

Platelet-Rich Plasma for the Treatment of Low Back Pain: a Comprehensive Review. Ivan Urits, Omar Viswanath, Annemarie C. Galasso, Emily R. Sottosani, Keenan M. Mahan, Christopher M. Aiudi, Alan D. Kaye & Vwaire J. Orhurhu . Current Pain and Headache Reports. Volume 23, article number: 52 (2019)

Minimally Invasive PRGF Treatment for Low Back Pain and Degenerative Disc Disease. Kirchner F. Anitua E. Platelet Rich Plasma in Orthopaedics and Sports Medicine pp 259-275 | Cite as

Biological Treatment Approaches for Degenerative Disc Disease.
Brenton Pennicooke,1 Yu Moriguchi,2 Ibrahim Hussain,2 Lawrence Bonssar,3 and Roger Härtl2

Do Regenerative Medicine Therapies Provide Long-Term Relief in Chronic Low Back Pain. Jaya Sanapati, MD1, Laxmaiah Manchikanti, MD2, Sairam Atluri, MD3, Sheldon Jordan, MD4 Sheri L. Albers, DO5, Miguel A. Pappolla, MD, PhD6, Alan D. Kaye, MD,
PhD7

Spinal Injections, Epidural Neurolysis and Denervation for Specific Low Back Pain and Sciatica. Andreas Veihelmann. Georg Thieme Verlag KG Stuttgart · New York

The use of lumbar epidural injection of platelet lysate for treatment of radicular pain. Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Matthew Hyzy, Christopher Williams & Michael Freeman . Journal of Experimental Orthopaedics. 4, Article number: 38 (2017)

The future of disc surgery and regeneration. Zorica Buser, Andrew S. Chung, Aidin Abedi & Jeffrey C. Wang. International Orthopaedics . Vol 43. Pages 995-1002 (2019)

Efficacy of Platelet-Rich Plasma Containing Xenogenic Adipose Tissue-Derived Stromal Cells on Restoring Intervertebral Disc. Chao Ma,1 Ran Wang,1 Dingliang Zhao,1 Naikun Wang,1 Ying Han,1 Shichong Wang,1 Tianyun Gao,2 Bin Wang,2 and Lijuan Pain research and Management . 2019

Tissue‐engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF‐β1 in platelet‐ rich plasma. Wei‐Hong Chen Wen‐Cheng Lo Jie‐Jen Lee Ching‐Hua Su Che‐Tong Lin. 05 September 2006. Journal of cellular Physiology.

Etude des effets du Plasma Riche en Plaquettes (PRP) sur les monodiscopathies peu évoluées
Charneux, Laurent. Université de Liège, Belgique .Département des sciences de la motricité, Kinésithérapie spécifique et réadaptation motrice . Sep-2016

Evaluation of platelet‐rich plasma and hydrostatic pressure regarding cell differentiation in nucleus pulposus tissue engineering
Antje Mietsch Cornelia Neidlinger‐Wilke Hubert Schrezenmeier. Tissue engineering and regenerative medicine. 12 December 2011

Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration Mikel Sánchez, Eduardo Anitua, Diego Delgado, Peio Sanchez, Roberto Prado, Gorka Orive. Biological Therapy, 15 Nov 2016.

Platelet-rich plasma, an adjuvant biological therapy to assist peripheral nerve repair. Mikel Sánchez,1,2 Ane Garate,2 Diego Delgado, Ph.D.,2,* and Sabino Padilla, M.D., Ph.D. Neural Regen Res. 2017 Jan; 12(1): 47–52.

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy. Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J. Williams, Matthew Hyzy, Thomas Ichim & Michael Freeman . Journal of Translational Medicine volume 15, Article number: 197 (2017)

Controlled Pilot Study Comparing Leucocyte‐Rich Platelet‐Rich Plasma and Corticosteroid in Caudal Epidural Injection for Complex Chronic Degenerative Spinal Pain. Ricardo Ruiz‐Lopez MD, FIPP Yu‐Chuan Tsai MD, FIPP Pain Practice. 07 April 2020

Platelet Rich Plasma in Musculoskeletal Practice. Jose Fabio Santos Duarte, Lana Eduardo Fonseca.
WegleinWilliam Dias BelangeroFabrício Dias AssisAndré Marques Mansano . Platelet-Rich Plasma in Pain Medicine . 2016

Regenerative Injection Therapy. Felix S. LinetskyAndrea M. TrescotMatthias H. Wiederhol. Pain Management and Palliative Care pp
369-375

Comparison of interlaminar CT-guided epidural platelet-rich plasma versus steroid injection in patients with lumbar radicular pain. Sylvain Bise, Benjamin Dallaudiere, Lionel Pesquer, Morad Pedram, Philippe Meyer, Myriame Bou Antoun, Arnaud Hocquelet & Alain Silvestre . European Radiology (2020)

A contemporary view of platelet-rich plasma therapies: moving toward refined clinical protocols and precise indications. Isabel Andia & Nicola Maffulli. REGENERATIVE MEDICINEVOL. 13, NO. 6 REVIEW

The Effectiveness and Safety of Percutaneous Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate for the Treatment of Suspected Discogenic Low Back Pain. Taylor Burnham, Aaron Conger, Quinn Tate, Daniel M. Cushman, Richard Kendall, Byron Schneider & Zachary L. McCormick . Current Physical Medicine and Rehabilitation Reports 2019

Platelet-rich plasma. Evidence, limits and future perspectives. A. Bove, B. Russo, Barile & N. Orabona . LO SCALPELLO-OTODI Educational. Volume 33. Pages, 220-225 (2019)